Health Hotline Magazine | August 2025

Increase Protection with Inflammation-Modulating Supplements

EPA

OMEGA 3

Omega-3 fatty acids. The omega-3 fats, EPA and DHA, are some of the most extensively studied dietary supplements for reducing inflammation; they have also been widely studied in relation to mental health. When it comes to anxiety and depression specifically, it appears that a higher ratio of EPA to DHA is the most e ective. A recent meta-analysis of 10 random-controlled trials including 1,426 patients indicates that a higher EPA:DHA ratio (60 percent or greater EPA) has the most antidepressant e ect, with doses between one and two grams/daily (of EPA) being the most e ective. A study investigating the omega-3’s e ect on inflammation and anxiety in medical students found that a dose of 2.5 grams omega-3 daily (2,085 EPA/348 DHA) for 12 weeks lead to a decrease in the production of inflammatory cytokines and a 20 percent reduction in anxiety symptoms. Because omega-3 fats are generally missing from the Western diet, to ensure optimal levels, supplementing is necessary.

DHA

Vitamin D. Add mental health to the long list of ways vitamin D supports health. When it comes to neuroinflammation, vitamin D packs a one-two punch, working on both the immune system and central nervous system. As already mentioned, an overactive immune response to stress, which leads to chronic inflammation, is implicated in the development of anxiety and depression; vitamin D is an immunomodulator, ensuring that the immune system neither over- nor under-responds when it is activated. Vitamin D also plays a critical role in the structure and function of the brain—there are vitamin D receptors in areas of the brain that control behavior and are involved in emotional processing, vitamin D regulates serotonin synthesis, and it has a neuroprotective e ect by modulating inflammation in the brain. Low vitamin D levels are associated with increased symptoms of both anxiety and depression. If you su er from anxiety and/or depression, consider having your vitamin D levels checked; deficiency is considered to be blood levels below 20 ng/mL while optimal levels are between 40 and 50 ng/mL.

Curcumin. Research shows that this polyphenol, found in turmeric, is one of the most e ective natural anti-inflammatories available, and because it can cross the blood-brain barrier and reach brain tissue, it’s especially e ective for neuroinflammation. Studies have found that oral administration of curcumin reduces the activity and number of a variety of pro-inflammatory molecules and preserves glutathione concentrations in the hippocampus, a part of the brain that plays a role in emotional regulation, including anxiety and “avoidance behaviors.” Glutathione is a powerful antioxidant produced by the body and has a protective e ect on brain cells in the presence of inflammation. Finally, curcumin has been shown to regulate neurotransmitters, especially serotonin, dopamine, and norepinephrine, a neurotransmitter that plays a critical role in the body’s stress response. A 2024 meta-analysis that included eight random-controlled trials with 567 participants found that curcumin intake had a significant e ect on relieving anxiety symptoms, particularly those with “greater intensity of anxiety.” It also found that taking curcumin for longer durations (12 weeks or more) in patients 45 years and under lead to more improvement in anxiety symptoms. Another study including patients with major depressive disorder found that 1,000 mg of curcumin daily, taken both with and without a common prescription anti-depressant, lead to a significant reduction in depression scores. Studies show that an e ective dose for mental health ranges between 1,000 mg and 2,000 mg/daily.

Anxiety and depression are complex mental health disorders that manifest for di erent reasons, but we know that underlying inflammation plays a significant role. There is no single magic fix, but by addressing the inflammation and using other tools in your mental health kit (talk therapy, mindfulness practices, exercise, etc.) you can be on your way to feeling your best again. You deserve it.

For references, please visit naturalgrocers.com/issue-97