Health Hotline Magazine | October 2022

been reported to have suppressed natural killer (NK) cell activity and decreased numbers of circulating lymphocytes (T-cells that kill infected cells and activate cells in the immune system). When treated with methyl-B 12 injections, their immune function improved, with researchers summarizing, “We conclude that vitamin B 12 acts as an immunomodulator for cellular immunity.” Folate deficiency also reduces T-cell levels that play a central role in immune response. According to the Linus Pauling Institute at Oregon State University, “Clinical folate deficiency, known as megaloblastic anemia, results in impaired immune responses, primarily a ecting cell-mediated immunity; and correcting the vitamin deficiency with folic acid supplementation restores the a ected immune functions.” Be Blood Sugar Balanced The B vitamins also play a pivotal role in glucose metabolism and blood sugar balance. Vitamin B 6 , and the biologically active form pyridoxal 5'-phosphate (PLP or sometimes referred to as P5P), is a cofactor for approximately 150 reactions, including those that regulate glucose metabolism. Some compelling studies have indicated a clear link between low vitamin B 6 levels and the development of diabetes, as well as a protective e ect of optimal levels of vitamin B 6 on complications in both type-1 and type-2 diabetes. Advanced glycation end products (AGEs) are formed in the body as a result of chronically high blood sugar and are a major contributor to the pathologic manifestations of diabetes, such as cardiovascular disease. Vitamins B 1 and B 6 were tested in vitro on human hemoglobin and researchers discovered that the two vitamins “potently inhibited AGE formation… suggesting that these two compounds may have novel therapeutic potential in preventing vascular complications of diabetes.” B 6 also counteracts the formation of reactive oxygen species, acting as an antioxidant and quenching free radicals. Along with a balanced diet, a B-complex vitamin is a perfect partner to support cellular energy production, healthy brain and nerve function, a healthy stress response and mood, immune function, and blood sugar balance. In fact, this back-to-basics approach may “B” just the ticket to good health.

Be Calm And Stress Less The B vitamins also support the brain and body’s ability to cope with stress. A 2019 review and meta-analysis sought to examine and quantify the e ects of B vitamin supplementation on mood in both healthy and “at-risk” populations due to poor nutrition or poor mood. Results found that supplementation with a B-vitamin complex supported mental wellbeing and overall mood compared to a placebo, especially related to stress. The meta-analysis concluded that B vitamin supplementation “may particularly benefit populations who are at-risk due to poor nutrient status or poor mood status.” Be Immune Strong & Be Well The B’s are so crucial for overall health, it may come as no surprise that they have a direct e ect on a healthy immune system, specifically B 6 , B 12 , and folate. B 6 is associated with the regulation of immune responses, including the inflammatory response, and supports the production of antibodies. Researchers have found that a B 6 deficiency reduces antibody formation, as well as the growth, proliferation, and activity of certain types of white blood cells, which are needed to help the body fight infections and diseases. B 12 is also critical for immune function and many are at risk of deficiency. Patients diagnosed with a vitamin B 12 deficiency have

Get to Know Your Bioactive B’s When it comes to maximizing the health benefits of the B vitamins, be sure to look for co-enzymated or "activated" on the label of your B complex, which indicates that it contains the forms of the B vitamins that our bodies can easily use. For references email

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